Stopping use of a drug often leads to a set of adverse symptoms known as what?

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Stopping use after regular use triggers withdrawal, a set of physical and psychological symptoms that arise when the body, having adapted to the drug, must readjust to functioning without it. This happens because the brain and body have compensatory changes to counteract the drug’s effects, so when the drug is removed, those systems rebound in a way that produces symptoms. Withdrawal is different from tolerance, which is needing more of the drug to achieve the same effect; from dependence, which is the overall state of relying on the drug; and from craving, which is the urge to seek the drug. So the adverse symptom cluster that appears after stopping is withdrawal.